Which of the following statements about Paget's disease is true?
It is a hereditary condition passed down through generations.
It is caused by vitamin D deficiency.
It primarily affects the hands and feet.
It is a rare condition with a prevalence of less than 1%.
The Correct Answer is A
Paget's disease has a genetic component, and there is evidence of familial inheritance. Individuals with a family history of Paget's disease are at a higher risk of developing the condition.
b. It is caused by vitamin D deficiency: Paget's disease is not caused by vitamin D deficiency. It is primarily a result of genetic factors leading to abnormal bone remodeling.
c. It primarily affects the hands and feet: Paget's disease can affect various bones in the body, not just the hands and feet. It commonly involves the pelvis, vertebrae, and ribs.
d. It is a rare condition with a prevalence of less than 1%: Paget's disease is not considered rare. It is relatively common, particularly in older adults, with a prevalence estimated to be around 1-3% in individuals over the age of 40.
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Correct Answer is D
Explanation
The most common clinical manifestation of Paget's disease is bone pain and deformities due to abnormal bone remodeling and increased bone turnover.
a. Severe joint pain: While joint pain can occur in Paget's disease due to bone involvement, it is not the most common manifestation. Bone pain and deformities are more characteristic.
b. Unexplained weight loss: Unexplained weight loss is not a typical symptom of Paget's disease. It is not directly related to the bone disorder.
c. Visual disturbances: Visual disturbances are not associated with Paget's disease. This condition primarily affects bones, not the eyes or vision.
Correct Answer is C
Explanation
X-ray imaging is commonly used to confirm the diagnosis of Paget's disease. X-rays can show characteristic bone changes, such as bone enlargement, thickening, and deformities, which are indicative of Paget's disease.
a. Bone density scan: While bone density scans may be useful to assess bone health in other conditions, they are not the primary diagnostic tool for Paget's disease. X-rays are preferred.
b. Magnetic resonance imaging (MRI): MRI may provide detailed images of bones and surrounding soft tissues, but it is not the first-line diagnostic test for Paget's disease. X-rays are more commonly used.
d. Blood glucose test: A blood glucose test is used to diagnose and monitor diabetes, not Paget's disease. These conditions are unrelated.
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