A group of nursing students are reviewing antineoplastic drugs.
The students demonstrate understanding of the information when they identify which of the following as cell cycle specific?

Alkylating agents.

Plant alkaloids.

Antineoplastic antibiotics.

Retinoids.

Answer and Explanation

The Correct Answer is B

Choice A rationale:

Alkylating agents. Alkylating agents are not cell cycle-specific. These agents work by directly binding to DNA and interfering with the cell's ability to replicate and divide. Their action is not limited to a specific phase of the cell cycle, making them non-cell cycle-specific agents. Alkylating agents are often used in cancer chemotherapy to prevent cell division and growth.

Choice C rationale:

Antineoplastic antibiotics. Antineoplastic antibiotics are not cell cycle-specific either. These drugs, such as doxorubicin and bleomycin, work by disrupting DNA and RNA synthesis and are used to treat various types of cancer. However, they do not specifically target cells in a particular phase of the cell cycle.

Choice D rationale:

Retinoids. Retinoids are not cell cycle-specific antineoplastic agents. Retinoids are compounds related to vitamin A and are used for various medical purposes, including some cancer treatments. However, their mechanism of action is not tied to a specific phase of the cell cycle, making them non-cell cycle-specific.

Choice B rationale:

Plant alkaloids. Plant alkaloids, such as vinca alkaloids (vincristine and vinblastine) and taxanes (paclitaxel), are considered cell cycle-specific antineoplastic drugs. These agents interfere with microtubule function, which is critical during mitosis (cell division). By disrupting microtubules, they specifically target rapidly dividing cancer cells during the M phase of the cell cycle. This selectivity for actively dividing cells makes plant alkaloids cell cycle-specific antineoplastic drugs.

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Correct Answer is A

Explanation

Choice A rationale:

Impaired hepatic function requires cautious use of antiretroviral therapy. Many antiretroviral drugs are metabolized in the liver, and impaired hepatic function can affect drug metabolism and lead to potential drug interactions and toxicity. Adjustments in antiretroviral therapy may be needed in individuals with liver impairment.

Choice B rationale:

Impaired renal function also requires cautious use of antiretroviral therapy. Some antiretroviral drugs are eliminated by the kidneys, and impaired renal function can affect drug clearance. Dosing adjustments and drug selection may be necessary in individuals with renal impairment to prevent drug accumulation and toxicity.

Choice C rationale:

Hypertension is not a specific condition that requires cautious use of antiretroviral therapy. While some antiretroviral drugs can have side effects related to blood pressure, such as protease inhibitors, hypertension itself is not a contraindication for antiretroviral therapy.

Choice D rationale:

COPD (Chronic Obstructive Pulmonary Disease) is not a specific condition that requires cautious use of antiretroviral therapy. Antiretroviral therapy is primarily used in the treatment of HIV, and COPD is a lung condition unrelated to HIV. The two conditions do not directly interact, and COPD is not a contraindication for antiretroviral therapy. .

A. Lymphoma. B. Angioneurotic edema. C. Acute renal failure. D. Reye's syndrome.

Correct Answer is D

Explanation

Choice A rationale:

Lymphoma is not a known adverse effect of aspirin use. Reye's syndrome, a rare but severe condition, is associated with aspirin use in children recovering from viral infections such as chickenpox or influenza. Therefore, it is important to be alert to the development of Reye's syndrome when aspirin is administered to a child with these infections.

Choice B rationale:

Angioneurotic edema is not a typical adverse effect of aspirin use in children with chickenpox. Reye's syndrome is the more relevant concern.

Choice C rationale:

Acute renal failure is not a direct result of aspirin use for fever in children. The primary concern in this context is Reye's syndrome, which affects the brain and liver.

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A group of nursing students are reviewing antineoplastic drugs.The students demonstrate understanding of the information when they identify which of the following as cell cycle specific?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A group of nursing students are reviewing information about antiretroviral therapy.The students demonstrate understanding of the information when they identify which conditions as requiring cautious use of this class of drugs?

Correct Answer is A

Explanation

The parents of a child who is recovering from chickenpox tell the nurse that they gave the child aspirin for his fever.The nurse would be alert to the development of which of the following?

Correct Answer is D

Explanation

After administering an antineoplastic drug, the nurse bases the ongoing assessment on which of the following factors?

A nursing instructor is preparing a teaching plan for a group of nursing students about macrolide antibacterial drugs.Which of the following would the instructor expect to include?

Which of the following should be included in the nurse's preadministration assessment before administering the first dose of an antineoplastic drug?

A client is prescribed ferrous sulfate (Feosol). Which of the following adverse reactions should the nurse discuss with a client prior to the administration of this drug?

After reviewing information about lincosamide therapy, a group of nursing students demonstrate understanding of the information when they identify which of the following as a contraindication?

A nurse is caring for a client brought to the health care facility for a drug overdose.In which of the following cases can the client be administered an emetic?

A client is in the initial treatment phase for tuberculosis.Which of the following antitubercular drugs would the nurse expect the client to receive during this phase?

When reviewing a client's history, a nurse determines that the use of laxatives would be contraindicated if the client has a history of which of the following?

A group of nursing students are reviewing antineoplastic drugs.
The students demonstrate understanding of the information when they identify which of the following as cell cycle specific?