A group of nursing students are reviewing antineoplastic drugs.
The students demonstrate understanding of the information when they identify which of the following as cell cycle specific?
Alkylating agents.
Plant alkaloids.
Antineoplastic antibiotics.
Retinoids.
The Correct Answer is B
Choice A rationale:
Alkylating agents. Alkylating agents are not cell cycle-specific. These agents work by directly binding to DNA and interfering with the cell's ability to replicate and divide. Their action is not limited to a specific phase of the cell cycle, making them non-cell cycle-specific agents. Alkylating agents are often used in cancer chemotherapy to prevent cell division and growth.
Choice C rationale:
Antineoplastic antibiotics. Antineoplastic antibiotics are not cell cycle-specific either. These drugs, such as doxorubicin and bleomycin, work by disrupting DNA and RNA synthesis and are used to treat various types of cancer. However, they do not specifically target cells in a particular phase of the cell cycle.
Choice D rationale:
Retinoids. Retinoids are not cell cycle-specific antineoplastic agents. Retinoids are compounds related to vitamin A and are used for various medical purposes, including some cancer treatments. However, their mechanism of action is not tied to a specific phase of the cell cycle, making them non-cell cycle-specific.
Choice B rationale:
Plant alkaloids. Plant alkaloids, such as vinca alkaloids (vincristine and vinblastine) and taxanes (paclitaxel), are considered cell cycle-specific antineoplastic drugs. These agents interfere with microtubule function, which is critical during mitosis (cell division). By disrupting microtubules, they specifically target rapidly dividing cancer cells during the M phase of the cell cycle. This selectivity for actively dividing cells makes plant alkaloids cell cycle-specific antineoplastic drugs.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Correct Answer is B
Explanation
Choice A rationale:
Administering a combination of drugs in TB treatment is not primarily aimed at preventing the incidence of liver dysfunction. The combination therapy's main objective is to address the complex nature of Mycobacterium tuberculosis infections and the potential development of antibiotic resistance.
Choice B rationale:
The nurse should explain that the primary reason for administering a combination of drugs is to slow down bacterial resistance. When TB is treated with a single drug, the bacteria can quickly develop resistance to that drug. Using a combination of drugs with different mechanisms of action makes it more difficult for the bacteria to develop resistance. This is a fundamental principle in the treatment of TB.
Choice C rationale:
Slowing the body's resistance to medication is not a goal in TB treatment. The focus is on preventing the development of resistance in the bacteria, not the body's response to the medication.
Choice D rationale:
While TB treatment aims to prevent the further spread of the disease, the primary reason for using a combination of drugs is to address bacterial resistance. Preventing the spread of TB is an important secondary benefit of effective treatment.
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