A group of nursing students are reviewing antineoplastic drugs.
The students demonstrate understanding of the information when they identify which of the following as cell cycle specific?
Alkylating agents.
Plant alkaloids.
Antineoplastic antibiotics.
Retinoids.
The Correct Answer is B
Choice A rationale:
Alkylating agents. Alkylating agents are not cell cycle-specific. These agents work by directly binding to DNA and interfering with the cell's ability to replicate and divide. Their action is not limited to a specific phase of the cell cycle, making them non-cell cycle-specific agents. Alkylating agents are often used in cancer chemotherapy to prevent cell division and growth.
Choice C rationale:
Antineoplastic antibiotics. Antineoplastic antibiotics are not cell cycle-specific either. These drugs, such as doxorubicin and bleomycin, work by disrupting DNA and RNA synthesis and are used to treat various types of cancer. However, they do not specifically target cells in a particular phase of the cell cycle.
Choice D rationale:
Retinoids. Retinoids are not cell cycle-specific antineoplastic agents. Retinoids are compounds related to vitamin A and are used for various medical purposes, including some cancer treatments. However, their mechanism of action is not tied to a specific phase of the cell cycle, making them non-cell cycle-specific.
Choice B rationale:
Plant alkaloids. Plant alkaloids, such as vinca alkaloids (vincristine and vinblastine) and taxanes (paclitaxel), are considered cell cycle-specific antineoplastic drugs. These agents interfere with microtubule function, which is critical during mitosis (cell division). By disrupting microtubules, they specifically target rapidly dividing cancer cells during the M phase of the cell cycle. This selectivity for actively dividing cells makes plant alkaloids cell cycle-specific antineoplastic drugs.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Correct Answer is B
Explanation
Choice A rationale:
Nizatidine is not a proton pump inhibitor; it is an H2 receptor antagonist. It works by blocking the histamine H2 receptors in the stomach, reducing acid production. Proton pump inhibitors (PPIs) work differently by directly inhibiting the proton pump (H+/K+ ATPase) responsible for acid secretion in the stomach.
Choice B rationale:
Omeprazole is a proton pump inhibitor (PPI). PPIs are drugs that reduce gastric acid production by inhibiting the proton pump (H+/K+ ATPase) in the parietal cells of the stomach. This action is highly effective in treating conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers.
Choice C rationale:
Sucralfate is not a proton pump inhibitor; it is a medication that forms a protective barrier over ulcers and erosions in the stomach and intestines. It does not directly affect acid production.
Choice D rationale:
Misoprostol is not a proton pump inhibitor; it is a synthetic prostaglandin E1 analog. It is primarily used to prevent gastric ulcers in individuals who are at high risk due to chronic nonsteroidal anti-inflammatory drug (NSAID) use. It has a protective effect on the gastric mucosa but does not inhibit acid secretion.
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