A nurse is caring for a patient who has been newly prescribed ondansetron (Zofran) for post-operative nausea. What is the mechanism of action for ondansetron?
Ondansetron agonizes serotonin receptors on afferent vagal neurons.
Ondansetron agonizes serotonin receptors in the medulla oblongata.
Ondansetron agonizes dopaminergic receptors in the vestibular apparatus.
Ondansetron blocks serotonin receptors in the chemoreceptor trigger zone.
The Correct Answer is D
A. Ondansetron agonizes serotonin receptors on afferent vagal neurons. – This is incorrect. Ondansetron works by blocking, not activating, serotonin (5-HT3) receptors in areas involved in nausea and vomiting.
B. Ondansetron agonizes serotonin receptors in the medulla oblongata. – This is incorrect. Ondansetron does not act as an agonist at serotonin receptors in the medulla oblongata; instead, it antagonizes receptors to reduce nausea.
C. Ondansetron agonizes dopaminergic receptors in the vestibular apparatus. – This is incorrect. Ondansetron does not affect dopaminergic receptors or the vestibular apparatus. Medications like promethazine address dopaminergic pathways.
D. Ondansetron blocks serotonin receptors in the chemoreceptor trigger zone. – This is correct. Ondansetron acts as a 5-HT3 receptor antagonist, blocking serotonin receptors in the chemoreceptor trigger zone and vagal nerve terminals, effectively preventing nausea and vomiting.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A. "This medication may cause increased libido." This is incorrect. Cimetidine (Tagamet) can cause side effects such as decreased libido, especially in men. This occurs because the drug inhibits the action of certain hormones, leading to sexual dysfunction.
B. "You may take this medication with antacids to prevent stomach upset." This is incorrect. Cimetidine should not be taken with antacids because antacids can reduce its absorption and effectiveness. It is advised to space the administration of cimetidine and antacids by at least 1 hour.
C. "This medication will neutralize your stomach acid." This is incorrect. Cimetidine works by blocking histamine receptors (H2 receptors), which reduces the production of stomach acid but does not neutralize it.
D. "This medication may cause decreased libido." This is correct. One of the side effects of cimetidine is reduced libido, particularly in male clients, due to its anti-androgenic effects.
Correct Answer is ["A","C"]
Explanation
A. "I should apply this patch behind my ear.": This is correct because the scopolamine patch is designed to be applied behind the ear, where it can effectively deliver medication through the skin.
B. "This patch should be replaced every 7 days.": This is incorrect because the scopolamine patch should be replaced every 72 hours (3 days), not every 7 days.
C. "I should not use a second patch if the initial patch is ineffective.": This is correct because using more than one patch at a time can lead to an overdose of the medication, which can cause serious side effects.
D. "Before putting on my patch, I should wipe the area with an alcohol swab.": This is incorrect because using an alcohol swab can irritate the skin and affect the absorption of the medication. The area should be clean and dry, but not cleaned with alcohol.
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