A nurse is discussing the genetic forms of Nephrogenic Diabetes Insipidus. Which of the following is an X-linked recessive form of the condition?
Autosomal dominant Nephrogenic Diabetes Insipidus
Autosomal recessive Nephrogenic Diabetes Insipidus
X-linked dominant Nephrogenic Diabetes Insipidus
X-linked recessive Nephrogenic Diabetes Insipidus
The Correct Answer is D
A) Incorrect. Autosomal dominant Nephrogenic Diabetes Insipidus is inherited in an autosomal dominant manner, not as an X-linked recessive trait.
B) Incorrect. Autosomal recessive Nephrogenic Diabetes Insipidus is inherited in an autosomal recessive manner, not as an X-linked recessive trait.
C) Incorrect. X-linked dominant inheritance is not associated with Nephrogenic Diabetes Insipidus. This condition can be caused by mutations in the AVPR2 gene (X-linked recessive) or the AQP2 gene (autosomal recessive).
D) Correct. X-linked recessive Nephrogenic Diabetes Insipidus is caused by mutations in the AVPR2 gene located on the X chromosome. It primarily affects males who inherit the mutated gene from their carrier mothers.
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Correct Answer is C
Explanation
A) Incorrect. Hypertension is not typically associated with Nephrogenic Diabetes Insipidus. It may occur due to other underlying conditions.
B) Incorrect. Hyponatremia (low sodium levels) is not a primary characteristic of Nephrogenic Diabetes Insipidus. In fact, it can lead to hypernatremia (high sodium levels) due to excessive loss of water.
C) Correct. The hallmark clinical manifestations of Nephrogenic Diabetes Insipidus are polyuria (excessive urination) and polydipsia (excessive thirst) due to the kidneys' inability to concentrate urine.
D) Incorrect. Hypoglycemia (low blood sugar) is not directly associated with Nephrogenic Diabetes Insipidus. This condition primarily affects water balance.
Correct Answer is A
Explanation
A) Correct. In Nephrogenic Diabetes Insipidus, the kidneys produce excessive amounts of dilute urine, leading to fluid loss. Drinking more water helps
replenish the lost fluids.
B) Incorrect. Drinking more water does not directly stimulate the production of antidiuretic hormone in Nephrogenic Diabetes Insipidus, as the primary issue lies in the kidneys' response to ADH.
C) Incorrect. While excessive thirst is a symptom of Nephrogenic Diabetes Insipidus, the main reason for increased water intake is to compensate for the excessive urine production.
D) Incorrect. Diluting urine to prevent kidney stones is not the primary reason for increased water intake in Nephrogenic Diabetes Insipidus.
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