After teaching a group of nursing students about antiprotozoal drugs, the instructor determines that the teaching was successful when the group identifies which of the following as an indication for use?

Choice A rationale:

This choice is not accurate because the severity of the infection is not the primary reason for the development of a superinfection. Superinfections occur due to disruptions in the normal bacterial flora, not because the drug is less effective in severe infections.

Choice B rationale:

This choice is also inaccurate. Superinfections do not occur as the original infection begins to clear. They are a result of antibiotic therapy, particularly with drugs like fluoroquinolones that disrupt the normal bacterial balance.

Choice C rationale:

Choice D rationale:

This choice is not appropriate as it does not provide the patient with useful information. It's essential to educate the patient about why the superinfection occurred.

Choice A rationale:

Macrolides are typically broad-spectrum antibiotics, not narrow-spectrum. They are effective against a wide range of bacteria, making them a valuable option for various infections.

Choice B rationale:

Macrolides are generally well-tolerated, and they are not contraindicated in clients with renal dysfunction. In fact, macrolides like azithromycin are often preferred in such cases due to their minimal renal excretion.

Choice C rationale:

Macrolides, specifically erythromycin, have been associated with ototoxicity, which can lead to hearing impairment. This side effect is relatively rare but can occur, especially with high doses or prolonged use. It's important for healthcare providers to monitor for this potential adverse effect.

Choice D rationale:

Macrolides are often used as an alternative for clients who are allergic to penicillins, so they can be used in this population when appropriate. The cross-reactivity between these drug classes is relatively low, and macrolides can be a suitable choice for penicillin-allergic individuals.