Antidiarrheals are contraindicated in clients whose diarrhea is associated with which of the following organisms that can harm the intestinal mucosa?

Choice A rationale:

Monitoring for the appearance of adverse reactions is a crucial aspect of managing a patient with TB undergoing treatment. TB medications can have side effects, and early detection of adverse reactions is essential for timely intervention. Some common adverse effects of TB drugs include hepatotoxicity, peripheral neuropathy, and gastrointestinal disturbances. By closely monitoring the patient, the nurse can ensure prompt action if these side effects occur, improving the patient's overall care and safety.

Choice B rationale:

Monitoring the patient's vital signs every 24 hours may be part of standard nursing care, but when managing a patient with TB, the primary focus should be on monitoring for adverse reactions to the TB medications. Vital signs are important but not the most critical aspect of care in this specific situation.

Choice C rationale:

Assessing the patient's history of contacts is essential for identifying potential sources of TB transmission. However, it is more related to the initial assessment and diagnosis of TB rather than ongoing assessment during treatment. The primary focus during treatment is monitoring the patient's response to medication and any adverse reactions.

Choice D rationale:

Using Directly Observed Therapy (DOT) to administer TB drugs is a standard practice to ensure treatment adherence. However, ongoing assessment should focus on monitoring for adverse reactions and treatment effectiveness rather than the administration method, which is usually established at the beginning of treatment.

Choice A rationale:

Protease inhibitors are a category of antiretroviral drugs used in the treatment of HIV. They work by affecting an enzyme called protease, which is necessary for the maturation of new viral particles. By inhibiting protease, these drugs prevent the formation of mature, infectious HIV particles.

Choice B rationale:

Reverse transcriptase inhibitors, including both nucleoside and non-nucleoside variants, target the enzyme reverse transcriptase. This enzyme is involved in the conversion of HIV RNA into DNA, an essential step in the viral life cycle. However, it's not about preventing the maturation of new viral particles, as mentioned in the question.

Choice C rationale:

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) also inhibit the reverse transcriptase enzyme, but they do so differently than protease inhibitors. While they are vital in HIV treatment, they do not specifically target the maturation of viral particles.

Choice D rationale:

Integrase inhibitors target the enzyme integrase, which is involved in the integration of viral DNA into the host cell's DNA. This step is crucial in the HIV life cycle, but it's not related to the maturation of new viral particles.