Identify substances that, when present in significant amounts in urine, may indicate a potential diabetic health issue. (Select all that apply)

A. Buildup of carbon dioxide in the blood: Rising arterial CO₂ (hypercapnia) is the primary stimulus for increased ventilation -central chemoreceptors detect CO₂-induced changes and drive respiratory rate/ depth.
B. pH levels in the cerebrospinal fluid: Central chemoreceptors in the medulla respond to lowered CSF pH (which reflects increased CO₂) and stimulate breathing -true and closely linked to CO₂ levels (mechanism of the primary drive).
C. Buildup of oxygen levels in the blood: Increased O₂ is not a stimulus for breathing; in fact, high oxygen reduces the hypoxic drive. Low O₂ (hypoxemia), not a buildup, can stimulate ventilation via peripheral chemoreceptors.
D. Rising blood pressure: Changes in blood pressure are sensed by baroreceptors and influence cardiovascular responses, but rising blood pressure is not a direct major stimulus for ventilation.

A. Calyx, nephron, collecting duct, urinary bladder, renal pelvis, ureter, urethra: Sequence is wrong -filtrate is formed in nephron, flows into collecting duct, then into calyx → renal pelvis → ureter → bladder → urethra.
B. Nephron, collecting duct, calyx, renal pelvis, ureter, urinary bladder, urethra: Urine forms in nephron → drains into collecting duct → minor/major calyces → renal pelvis → ureter → urinary bladder → urethra for elimination.
C. Nephron, renal pelvis, collecting duct, calyx, urinary bladder, urethra, ureter:Renal pelvis and calyx order is swapped relative to collecting duct; ureter/bladder order is wrong.
D. Collecting duct, nephron, renal pelvis, calyx, urinary bladder, ureter, urethra:Collecting duct follows the nephron (not precedes it); calyx and pelvis ordering is