Males are more likely than females to be affected by:
Autosomal-recessive disorders
Autosomal-dominant disorders
Chromosomal nondisjunction
X-linked (Sex) disorders
The Correct Answer is D
Choice A reason: Autosomal-recessive disorders affect both males and females equally because the gene in question is located on one of the autosomes (non-sex chromosomes). Each individual has two copies of each autosomal gene, one from each parent. An autosomal-recessive disorder manifests when an individual inherits two copies of a mutant gene, one from each parent. Therefore, gender does not influence the likelihood of being affected.
Choice B reason: Autosomal-dominant disorders also affect both males and females equally. These disorders occur when a single copy of a mutant gene on an autosome is sufficient to cause the disorder. Since autosomes are present in both males and females equally, the likelihood of inheriting an autosomal-dominant disorder is not influenced by gender.
Choice C reason: Chromosomal nondisjunction refers to errors in cell division that result in an abnormal number of chromosomes. While some conditions resulting from chromosomal nondisjunction can show gender bias (such as Turner syndrome affecting females and Klinefelter syndrome affecting males), it is not accurate to say that males are generally more likely than females to be affected by chromosomal nondisjunction.
Choice D reason: X-linked (sex-linked) disorders are more likely to affect males than females because the gene causing the disorder is located on the X chromosome. Males have one X and one Y chromosome (XY), while females have two X chromosomes (XX). If a male inherits a mutant gene on the X chromosome, he will express the disorder because he does not have a second X chromosome to mask the effect. In contrast, females would need two copies of the mutant gene (one on each X chromosome) to express the disorder, making it less likely for them to be affected.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: There is not a 25% chance that the offspring will be a carrier. In the case of recessive disorders, if one parent is affected (homozygous recessive) and the other parent is a carrier (heterozygous), the offspring has a different probability of being a carrier or affected.
Choice B reason: There is a 50% chance that the offspring will be a carrier. If the mother is affected (aa) and the father is a carrier (Aa), each child has a 50% chance of inheriting one recessive allele (a) from the mother and one normal allele (A) from the father, making them a carrier (Aa).
Choice C reason: There is not a 75% chance that the offspring will be a carrier. The probability of the offspring being a carrier or affected follows specific Mendelian inheritance patterns, which do not result in a 75% carrier rate.
Choice D reason: There is not a 100% chance that the offspring will be a carrier. While there is a significant likelihood of the offspring being affected or a carrier, it is not guaranteed that all offspring will be carriers.
Correct Answer is C
Explanation
Choice A reason: Compensated metabolic acidosis is characterized by a low pH (acidemia) with a compensatory decrease in PaCO2 due to hyperventilation, and typically a low HCO3 as well. In this scenario, the pH is elevated (alkalemia), which rules out metabolic acidosis.
Choice B reason: Compensated metabolic alkalosis is characterized by a high pH (alkalemia) with a compensatory increase in PaCO2 due to hypoventilation, and a high HCO3. In this case, the PaCO2 is low rather than high, and the HCO3 is within the normal range, which rules out metabolic alkalosis.
Choice C reason: Respiratory alkalosis is characterized by a high pH (alkalemia) and a low PaCO2, indicating that the alkalosis is due to excessive loss of CO2 through hyperventilation. The HCO3 is usually normal or slightly decreased as a compensatory mechanism. The provided ABG values (pH = 7.53, PaCO2 = 23, HCO3 = 22) are consistent with respiratory alkalosis, where the elevated pH and low PaCO2 point towards hyperventilation as the cause of the alkalemia.
Choice D reason: Uncompensated respiratory alkalosis would present with a high pH and low PaCO2, without significant compensation by the kidneys (i.e., HCO3 would still be normal). In this scenario, the ABG values fit the description of respiratory alkalosis, but it is considered compensated since the HCO3 is within the normal range, indicating some level of renal compensation.
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