Obesity is a major risk factor for the development of type 2 diabetes. What is the mechanism for this?
Obesity is associated with hypercholesterolemia, which impairs the circulation of insulin.
Obesity is a result of high sugar intake, which leads to hyperglycemia.
Obesity releases fatty acids and cytokines, which interfere with insulin receptors.
Obesity is associated with a mutation of the MiR-21 gene, which is the same gene implicated in the development of insulin resistance.
The Correct Answer is C
Choice A reason: While obesity can be associated with hypercholesterolemia, this condition primarily affects lipid levels and cardiovascular health rather than directly impairing insulin circulation.
Choice B reason: Obesity is not solely a result of high sugar intake. While diet plays a role, obesity involves a complex interplay of genetic, environmental, and lifestyle factors. High sugar intake can contribute to weight gain, but it is not the direct cause of obesity.
Choice C reason: Obesity releases fatty acids and cytokines, which interfere with insulin receptors. Adipose tissue in obese individuals releases pro-inflammatory cytokines and fatty acids that can cause insulin resistance by interfering with insulin signaling pathways.
Choice D reason: Obesity is not directly associated with a mutation of the MiR-21 gene. While genetic factors can contribute to obesity and type 2 diabetes, the primary mechanism involves metabolic and inflammatory pathways rather than specific gene mutations.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A reason: Type 1 diabetes cannot be treated with oral glycemic agents. These medications are typically used to manage type 2 diabetes, which is characterized by insulin resistance rather than a lack of insulin production. In type 1 diabetes, the pancreas is unable to produce insulin due to an autoimmune destruction of insulin-producing beta cells. Therefore, individuals with type 1 diabetes require insulin therapy to manage their blood glucose levels effectively.
Choice B reason: Type 1 diabetes has a definite genetic component, though it is not solely determined by genetics. A combination of genetic predisposition and environmental factors, such as viral infections or other autoimmune triggers, can lead to the development of type 1 diabetes. Certain genes, including those in the HLA region, are known to increase susceptibility to the disease.
Choice C reason: In type 1 diabetes, the pancreas is indeed completely unable to produce insulin. This is due to an autoimmune attack on the beta cells of the pancreas, which are responsible for insulin production. Without insulin, the body cannot regulate blood glucose levels, leading to hyperglycemia and the need for exogenous insulin administration.
Choice D reason: Type 1 diabetes often has an acute onset, particularly in children and young adults. Symptoms can develop rapidly over a few days to weeks, including increased thirst, frequent urination, unintended weight loss, and severe fatigue. This acute presentation is a hallmark of the disease and contrasts with the more gradual onset seen in type 2 diabetes.
Correct Answer is B
Explanation
Choice A reason: Gestational diabetes is a form of diabetes that occurs during pregnancy and typically resolves after childbirth. It is not typically associated with Hyperglycemic Hyperosmolar Nonketoic (HHNK) Syndrome, which is a specific complication of type 2 diabetes.
Choice B reason: Type 2 diabetes is characterized by insulin resistance and high blood glucose levels. HHNK is a serious acute complication of type 2 diabetes, occurring when blood glucose levels become extremely high, leading to severe dehydration and hyperosmolarity without significant ketoacidosis. This condition requires immediate medical attention.
Choice C reason: While both type 1 and type 2 diabetes involve issues with blood glucose regulation, HHNK is specifically associated with type 2 diabetes. Type 1 diabetes complications more commonly include Diabetic Ketoacidosis (DKA), rather than HHNK.
Choice D reason: Type 1 diabetes is characterized by the body's inability to produce insulin, leading to high blood glucose levels. However, the primary acute complication of type 1 diabetes is Diabetic Ketoacidosis (DKA), not HHNK. HHNK is distinct to type 2 diabetes, where insulin resistance leads to extremely high blood glucose levels and severe dehydration.
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