What are considered the ‘Big Three’ properties of an ideal drug? (Select all that apply)

Selectivity

Safety

Effectiveness

Irreversible action

A recognizable trade name

Answer and Explanation

Correct Answer : A,B,C

Choice A reason: Selectivity ensures a drug targets specific receptors, minimizing side effects. This is a key property of an ideal drug, making it a correct choice.

Choice B reason: Safety is critical, ensuring the drug causes minimal harm at therapeutic doses. This is a fundamental ideal drug property, so it is correct.

Choice C reason: Effectiveness ensures the drug achieves its intended therapeutic effect. This is essential for an ideal drug, making it a correct choice.

Choice D reason: Irreversible action is not ideal; reversible effects allow control and safety. The ‘Big Three’ focus on efficacy, safety, and selectivity, so this is incorrect.

Choice E reason: A trade name aids marketing but is not a pharmacological property. Effectiveness, safety, and selectivity are primary, so this is incorrect.

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Correct Answer is D

Explanation

Choice A reason: Pseudoephedrine, a decongestant, relieves nasal congestion by vasoconstriction but doesn’t address inflammation or histamine-mediated symptoms like sneezing or itching in rhinitis. It’s less effective than intranasal corticosteroids, which target the underlying allergic response, making this choice less optimal for comprehensive rhinitis treatment.

Choice B reason: Intranasal cromolyn sodium stabilizes mast cells, reducing histamine release, but it’s less effective than corticosteroids for rhinitis. Atrovent (ipratropium) is incorrectly referenced here, as it treats rhinorrhea, not inflammation. Corticosteroids like fluticasone are preferred, making this choice incorrect for optimal treatment.

Choice C reason: Propranolol, a beta-blocker, treats hypertension and cardiac conditions, not rhinitis. It has no effect on allergic inflammation, histamine, or nasal congestion. Its use in rhinitis could worsen symptoms by causing bronchoconstriction in asthmatics, making this choice inappropriate and incorrect.

Choice D reason: Fluticasone propionate, an intranasal corticosteroid, reduces inflammation, edema, and histamine effects in seasonal and perennial rhinitis. It targets the allergic cascade, decreasing nasal congestion, sneezing, and itching, making it the most effective and guideline-recommended treatment, thus the correct choice for rhinitis management.

A. This route allows more rapid absorption of the drug B. This route prevents inactivation of the drug by digestive enzymes C. This route is the best way to control serum drug levels D. This route is safer, less expensive, and more convenient

Correct Answer is D

Explanation

Choice A reason: Enteral (oral) administration typically has slower absorption than intravenous routes due to first-pass metabolism in the liver and variable gastric emptying. While effective for many drugs, it’s not faster than parenteral routes, making this choice incorrect for describing the primary advantage of enteral administration.

Choice B reason: Some enteral drugs are inactivated by digestive enzymes or liver metabolism (first-pass effect), not prevented. Special formulations (e.g., enteric-coated) may protect drugs, but this isn’t a general advantage of the enteral route, which often faces enzymatic degradation, making this choice inaccurate.

Choice C reason: Enteral administration does not offer superior control of serum drug levels compared to intravenous routes, which provide precise dosing and immediate bioavailability. Oral drugs face variable absorption and first-pass metabolism, leading to less predictable levels, making this choice incorrect for enteral benefits.

Choice D reason: Enteral administration is safer (avoids injection risks like infection), less expensive (no need for sterile equipment), and more convenient (self-administered at home). These advantages make it preferable for many drugs, aligning with patient compliance and cost-effectiveness, making this the correct choice for the nurse’s response.

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What are considered the ‘Big Three’ properties of an ideal drug? (Select all that apply)

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Naxlex Comprehensive Predictor Exams

A patient says to the nurse what type of medications would be most effective for treating seasonal and perennial rhinitis. Which response by the nurse is correct?

Correct Answer is D

Explanation

A nurse is giving an enteral medication. The patient asks why this method is preferable for this drug. How will the nurse reply?

Correct Answer is D

Explanation

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What are considered the ‘Big Three’ properties of an ideal drug? (Select all that apply)

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