Which of the following medication classes can be used to treat PUD/GERD? (Select all that apply)
NSAIDs
Antacids
Laxatives
H2 antagonists
Proton pump inhibitors
Correct Answer : B,D,E
Choice A reason: NSAIDs, like ibuprofen, exacerbate peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) by inhibiting COX-1, reducing protective gastric mucus and increasing acid-related damage. They are contraindicated in these conditions, making this choice incorrect for treatment.
Choice B reason: Antacids neutralize gastric acid, providing rapid symptom relief in PUD and GERD by reducing acid irritation on the esophagus and stomach lining. They are a standard, non-prescription option for mild symptoms, making this a correct choice for managing these conditions.
Choice C reason: Laxatives treat constipation by promoting bowel movements but have no role in PUD or GERD, which involve acid-related damage to the stomach or esophagus. They don’t affect gastric acid or mucosal protection, making this choice incorrect for treatment.
Choice D reason: H2 antagonists, like ranitidine, reduce gastric acid secretion by blocking histamine receptors on parietal cells, promoting ulcer healing and relieving GERD symptoms. They are a mainstay treatment for both conditions, making this a correct choice for effective management.
Choice E reason: Proton pump inhibitors, like omeprazole, strongly inhibit gastric acid production by blocking the proton pump in parietal cells, allowing ulcer healing and reducing GERD symptoms. They are first-line therapy for PUD and GERD, making this a correct choice.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A reason: Respiratory acidosis has low pH and high PaCO2. High pH (7.47) and low PaCO2 (32) indicate alkalosis, not acidosis, so this incorrect.
Choice B reason: Metabolic acidosis has low pH and HCO3-. High pH and normal HCO3- (23) rule this out, pointing to respiratory alkalosis, so this is incorrect.
Choice C reason: Metabolic alkalosis has high pH and high HCO3-.. Normal HCO3- and low PaCO2 indicate respiratory alkalosis, so this is incorrect.
Choice D reason: High pH (7.47) and low PaCO2 (32) with normal CO2 HCO3- confirm respiratory alkalosis due to hyperventilation. This is matches, so it’s correct.
Correct Answer is A
Explanation
Choice A reason: Beta 1-adrenergic drugs, like dobutamine, stimulate beta-1 receptors in the heart, increasing cyclic AMP and calcium influx, enhancing myocardial contractility. This increases stroke volume by strengthening heart contractions, directly improving cardiac output, making this the correct choice for the drug’s mechanism of action.
Choice B reason: Cardiac afterload is the resistance the heart pumps against. Beta 1-adrenergic drugs don’t directly reduce afterload; they increase contractility. Increasing afterload would decrease stroke volume, opposing the drug’s purpose, making this choice incorrect for the drug’s effect on stroke volume.
Choice C reason: Venous return affects preload, not directly influenced by beta 1-adrenergic drugs. These drugs enhance contractility, increasing stroke volume independently of venous return. While preload impacts output, it’s not the primary mechanism of beta-1 stimulation, making this choice incorrect.
Choice D reason: Cardiac preload is the initial stretch of the heart, influenced by venous return. Beta 1-adrenergic drugs increase contractility, not preload, to boost stroke volume. Preload changes are secondary and not the primary action of these drugs, making this choice incorrect.
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