What is the best reason that drug toxicity can occur as a result of an age-related change in the liver?
Rapid blood flow through the liver
Decreased liver enzyme activity
Fluid accumulation in the portal vein
Increased liver size
The Correct Answer is B
A. Rapid blood flow through the liver
Blood flow to the liver actually decreases with age, which may impair drug metabolism, not accelerate it.
B. Decreased liver enzyme activity
Liver enzyme activity declines with age, reducing the liver’s ability to metabolize drugs, increasing the risk for toxicity.
C. Fluid accumulation in the portal vein
This is associated with portal hypertension in liver disease, not a normal age-related change.
D. Increased liver size
The liver tends to decrease in size and mass with age, not increase.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. Encourage the patient to talk to the primary care physician about the problem
While involving the PCP is helpful, the nurse can provide direct, effective care and education first.
B. Establishing a medication regimen to control the discomfort
Medication may be necessary in severe cases, but non-pharmacologic measures like moisturizing are safer and often more effective initially.
C. Encourage the patient to take a tepid bath and use moisturizers
Tepid baths prevent skin dryness, and applying moisturizers helps restore the skin barrier, relieving pruritus.
D. Teach the patient that pruritus is an expected consequence of aging
While more common with aging, pruritus should not be dismissed; it is treatable and can significantly affect quality of life.
Correct Answer is A
Explanation
A. Decreased impulse conduction speed
Aging causes slower nerve conduction due to loss of myelin and reduced neurotransmitter activity, leading to slower reflexes and response times.
B. Atherosclerosis and decreased cellular respiration
These factors affect circulation and energy production but are not primary causes of slowed neurologic responses.
C. Inadequate tissue oxygenation
Can affect brain function acutely, but it's not the main cause of chronic, gradual slowing in the elderly.
D. Loss of neurons in the brain
While this occurs with aging, slowed reflexes are more specifically linked to nerve impulse transmission rather than neuron quantity alone.
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