What is the best reason that drug toxicity can occur as a result of an age-related change in the liver?
Rapid blood flow through the liver
Decreased liver enzyme activity
Fluid accumulation in the portal vein
Increased liver size
The Correct Answer is B
A. Rapid blood flow through the liver
Blood flow to the liver actually decreases with age, which may impair drug metabolism, not accelerate it.
B. Decreased liver enzyme activity
Liver enzyme activity declines with age, reducing the liver’s ability to metabolize drugs, increasing the risk for toxicity.
C. Fluid accumulation in the portal vein
This is associated with portal hypertension in liver disease, not a normal age-related change.
D. Increased liver size
The liver tends to decrease in size and mass with age, not increase.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. Inadequate hydration: Can contribute to thickened secretions but is not the primary age-related factor in respiratory infections.
B. Decreased physical activity: May contribute indirectly to overall health decline but is not specific to infection risk.
C. Decreased ciliary action: Aging reduces ciliary function in the respiratory tract, impairing the clearance of pathogens and increasing infection risk.
D. Poor personal hygiene: While hygiene is important, it is not a typical physiologic age-related factor for respiratory infection.
Correct Answer is ["B","C","D","E","F"]
Explanation
A. Intellectual capability: Intellectual ability generally remains intact with age, unless affected by disease such as dementia.
B. Tolerance for extremes in temperature: Decreases due to impaired thermoregulation and thinner skin.
C. Total body water: Decreases, making older adults more susceptible to dehydration and electrolyte imbalances.
D. Force of pulse: May decrease due to decreased cardiac output and vascular elasticity.
E. Pulmonary gas exchange: Decreases due to changes in alveolar surface area and chest wall compliance.
F. Conduction speed of CNS impulses: Decreases, leading to slower reaction times and reflexes.
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