What situation(s) may cause an intrarenal acute kidney injury (AKI)? (Select all that apply)

Choice A reason: Acute infections are not defined by location but by rapid onset and severity. While some infections may be localized, the hallmark is their abrupt, intense presentation, resolving quickly with treatment or spontaneously, making this choice incomplete and incorrect for fully describing acute infections.

Choice B reason: Acute infections are characterized by rapid onset, severe symptoms, and short duration, typically resolving within days to weeks. This reflects the body’s immediate immune response to pathogens, causing intense but transient symptoms, such as fever or pain, making this the correct choice.

Choice C reason: Non-apparent, prolonged symptoms describe subclinical or chronic infections, not acute ones. Acute infections present with noticeable, severe symptoms that resolve quickly, not persisting asymptomatically, making this choice incorrect for the characteristics of acute infections.

Choice D reason: Less severe, prolonged symptoms describe chronic infections, like tuberculosis, not acute infections. Acute infections feature rapid, intense symptoms that resolve quickly, not mild symptoms over time, making this choice incorrect for describing acute infections.

Choice A reason: Graves’ disease, a form of hyperthyroidism, does not typically cause decreased calcium. It may lead to hypercalcemia due to increased bone resorption from elevated thyroid hormone levels, which enhance osteoclast activity, making decreased calcium an incorrect laboratory finding for this condition.

Choice B reason: Graves’ disease is characterized by increased thyroid hormone production, including elevated T4 due to autoimmune stimulation of the thyroid. Decreased T4 is associated with hypothyroidism, not hyperthyroidism, making this choice incorrect as it contradicts the pathophysiology of Graves’ disease.

Choice C reason: Increased TSH is seen in primary hypothyroidism, where the thyroid is underactive. In Graves’ disease, TSH is typically decreased due to negative feedback from elevated thyroid hormones (T3 and T4), making this choice incorrect for the expected laboratory profile.

Choice D reason: Graves’ disease causes hyperthyroidism, with increased production of thyroid hormones, including T3, due to autoantibodies stimulating TSH receptors. Elevated T3 levels drive metabolic symptoms like weight loss and tachycardia, making this the correct laboratory finding for Graves’ disease.