What is a manifestation of hypoparathyroidism?

Choice A reason: Photophobia, sensitivity to light, is not associated with hypothyroidism. It occurs in conditions like migraines or meningitis. Hypothyroidism slows metabolism, causing fatigue, not light sensitivity, making this choice incorrect.

Choice B reason: Exophthalmos, protruding eyes, is associated with hyperthyroidism (Graves’ disease) due to orbital inflammation. Hypothyroidism does not cause eye protrusion, making this choice incorrect for hypothyroidism manifestations.

Choice C reason: Weight loss is typical of hyperthyroidism due to increased metabolism. Hypothyroidism slows metabolism, causing weight gain, not loss, due to reduced energy expenditure, making this choice incorrect.

Choice D reason: Hypothyroidism reduces thyroid hormone levels, slowing metabolism and causing lethargy, fatigue, and reduced energy. This is a hallmark symptom due to decreased cellular activity, making this the correct choice.

Choice A reason: Pyelonephritis, a bacterial kidney infection, causes intrarenal AKI by directly damaging renal parenchyma through inflammation and tubular injury. The infection disrupts nephron function, reducing filtration and leading to acute kidney injury, making this a correct cause of intrarenal damage.

Choice B reason: Nephrotoxins, such as certain drugs or chemicals, cause intrarenal AKI by directly injuring tubular epithelial cells. This disrupts renal filtration and reabsorption, leading to acute kidney injury through toxic cellular damage, making this a correct cause of intrarenal AKI.

Choice C reason: A bladder tumor causes postrenal AKI by obstructing urine outflow, leading to backpressure on the kidneys. It does not directly damage renal parenchyma, as intrarenal AKI requires, making this choice incorrect for intrarenal causes of kidney injury.

Choice D reason: Dehydration causes prerenal AKI by reducing blood volume and renal perfusion, not directly damaging the renal parenchyma. Intrarenal AKI involves intrinsic kidney damage, so dehydration’s hypoperfusion effect makes this choice incorrect for intrarenal AKI.

Choice E reason: Ureteral obstruction causes postrenal AKI by blocking urine flow, increasing pressure on the kidneys. It does not involve direct parenchymal damage, as required for intrarenal AKI, making this choice incorrect for the specified type of kidney injury.