Which are therapeutic uses of verapamil? (Select all that apply)

Choice A reason: Lipid-soluble drugs cross cell membranes quickly due to their affinity for lipid bilayers, leading to predictable, rapid absorption. Their onset is not unpredictable but typically faster than water-soluble drugs, especially via routes like intravenous or transdermal, making this choice incorrect for lipid-soluble drugs.

Choice B reason: Lipid-soluble drugs, like fentanyl, rapidly cross lipid-rich cell membranes, including the blood-brain barrier, leading to quick onset of action. This is due to their high partition coefficient, allowing fast diffusion into tissues, making rapid effect onset the correct expectation for the nurse.

Choice C reason: Lipid-soluble drugs have faster onset than water-soluble drugs due to easier membrane penetration. Slow effects are more typical of water-soluble or poorly absorbed drugs. Lipid solubility enhances rapid distribution and action, making this choice incorrect for the expected effect timeline.

Choice D reason: Osmosis refers to water movement across membranes, not drug absorption. Lipid-soluble drugs diffuse through lipid bilayers, not via osmosis, which is irrelevant to their pharmacokinetics. This choice is scientifically inaccurate for describing the onset of lipid-soluble drug effects.

Choice A reason: Hyperthyroidism involves elevated T3 and T4 with low TSH due to excessive thyroid hormone production. The patient’s low T3/T4 and high TSH indicate reduced thyroid activity, not overactivity, as the pituitary increases TSH to stimulate the underactive thyroid, making this choice incorrect.

Choice B reason: Hypothyroidism is characterized by low T3 and T4 levels due to underactive thyroid function, prompting the pituitary to secrete more TSH to stimulate hormone production. This matches the patient’s lab results (low T3/T4, high TSH), often seen in primary hypothyroidism, making this the correct choice.

Choice C reason: Thyroid cancer may alter thyroid function but typically doesn’t present with consistently low T3/T4 and high TSH. It’s more likely to cause nodules or abnormal growths, not this specific hormonal pattern, which aligns with hypothyroidism, making this choice less likely.

Choice D reason: Pituitary adenoma causing secondary hypothyroidism would lower TSH, T3, and T4 due to impaired pituitary function. High TSH with low T3/T4 suggests primary thyroid failure, not pituitary dysfunction, making this choice incorrect for the patient’s hormonal profile.