Which of the following are correct about acute glomerulonephritis: (Select all that apply)
Clinical manifestations: hematuria (urine is smoky, brown tinged)
Clinical manifestations: oliguria
Treatment: Antibiotics, corticosteroids, cytotoxic agents, anticoagulants
Treatment: Prescription dose ibuprofen
Clinical manifestations: Proteinuria that exceeds 3-5g/day with albumin
Correct Answer : A,B,C
A. Clinical manifestations: hematuria (urine is smoky, brown tinged): Hematuria is a hallmark sign of acute glomerulonephritis. The smoky or cola-colored urine results from red blood cells leaking through the damaged glomeruli, often seen in post-infectious cases.
B. Clinical manifestations: oliguria: Decreased urine output is common due to impaired glomerular filtration. Oliguria reflects reduced kidney function, which contributes to fluid retention, hypertension, and accumulation of waste products.
C. Treatment: Antibiotics, corticosteroids, cytotoxic agents, anticoagulants: Depending on the cause and severity, treatment may include antibiotics for infection, corticosteroids or cytotoxic agents for inflammation, and anticoagulants if there's risk of thrombosis due to nephrotic syndrome features.
D. Treatment: Prescription dose ibuprofen: NSAIDs like ibuprofen are generally avoided in glomerulonephritis because they can reduce renal perfusion and worsen kidney injury, especially in patients already experiencing compromised kidney function.
E. Clinical manifestations: Proteinuria that exceeds 3–5g/day with albumin: This level of proteinuria is characteristic of nephrotic syndrome, not acute glomerulonephritis. While proteinuria may be present, it is typically moderate and not in the nephrotic range.
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Related Questions
Correct Answer is ["A","B","C","D","E"]
Explanation
A. Secretions include amylase: Amylase is a digestive enzyme secreted by the pancreas that helps break down carbohydrates. Elevated serum amylase is a common diagnostic marker in acute pancreatitis.
B. Contains proteolytic enzymes that break down dietary proteins: The pancreas produces proteolytic enzymes like trypsin and chymotrypsin, which digest proteins in the small intestine under normal conditions.
C. Pancreatic enzymes auto-digest pancreatic cells and tissue: In acute pancreatitis, premature activation of these enzymes inside the pancreas leads to self-digestion and inflammation of pancreatic tissue.
D. A reversible inflammatory process: Acute pancreatitis is typically reversible with prompt treatment, unlike chronic pancreatitis which involves permanent structural damage and functional loss.
E. Cardinal manifestation is abdominal pain – could be midabdominal, could be epigastric: Severe abdominal pain is the hallmark symptom, commonly located in the epigastric or midabdominal region and may radiate to the back.
Correct Answer is D
Explanation
A. Azotemia: Azotemia, or elevated blood urea nitrogen (BUN) and creatinine levels, is a common feature of glomerulonephritis due to reduced kidney filtration capacity and accumulation of nitrogenous wastes in the blood.
B. Hematuria with red cell casts: Hematuria with red blood cell casts is a classic hallmark of glomerulonephritis, indicating glomerular bleeding and inflammation. These casts are formed in the nephron and reflect active glomerular injury.
C. Oliguria and hypertension: Both are characteristic findings in glomerulonephritis. Oliguria results from impaired filtration, while hypertension develops due to fluid retention and activation of the renin-angiotensin-aldosterone system.
D. An increased glomerular filtration rate (GFR) of >100: Glomerulonephritis typically leads to a decreased GFR, not an increase. Inflammation and damage to the glomeruli impair the kidneys' ability to filter blood effectively, resulting in reduced GFR and waste accumulation.
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