Which of the following has the highest risk for EPS?
aripiprazole (Abilify)
clozapine (Clozaril)
lurasidone (Latuda)
haloperidol (Haldol)
The Correct Answer is D
A. Aripiprazole (Abilify) is a second-generation (atypical) antipsychotic with a lower risk of extrapyramidal symptoms (EPS) due to its partial dopamine agonist mechanism. It has a lower incidence of tardive dyskinesia and dystonia compared to typical antipsychotics.
B. Clozapine (Clozaril) has the lowest risk of EPS among antipsychotics because it weakly blocks D2 receptors and primarily targets serotonin (5-HT2A) receptors. However, it carries a high risk of agranulocytosis, sedation, and metabolic syndrome.
C. Lurasidone (Latuda) is a second-generation antipsychotic with a moderate risk of EPS, particularly akathisia (restlessness). However, it has a lower risk than first-generation (typical) antipsychotics like haloperidol.
D. Haloperidol (Haldol) is a first-generation (typical) antipsychotic with a high risk of EPS due to its strong dopamine (D2) receptor blockade. It is associated with dystonia, akathisia, parkinsonism, and tardive dyskinesia, making it the antipsychotic with the highest EPS risk in this list.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. Fetal alcohol syndrome (FAS) is a leading preventable cause of intellectual disability. Prenatal alcohol exposure disrupts brain development, leading to cognitive impairment, behavioral problems, and facial abnormalities.
B. Down syndrome (trisomy 21) is a genetic disorder that causes intellectual disability, developmental delays, and characteristic physical features. It results from an extra copy of chromosome 21, affecting brain development and cognitive function.
C. Serotonin syndrome is an acute, life-threatening condition caused by excessive serotonin activity due to medication overdose or drug interactions (e.g., SSRIs, MAOIs, MDMA). Symptoms include hyperreflexia, autonomic instability, and altered mental status, but it does not cause intellectual disability.
D. Fragile X syndrome is a genetic disorder caused by a mutation in the FMR1 gene on the X chromosome. It is the most common inherited cause of intellectual disability, leading to cognitive impairments, social anxiety, and hyperactivity, often resembling autism spectrum disorder (ASD).
Correct Answer is C
Explanation
A. Needs to be taken care of. Individuals with dependent personality disorder (DPD) have an excessive need for care and reassurance. They rely heavily on others to make decisions and take responsibility for their daily life.
B. Conflict avoidance. People with DPD avoid conflict and disagreement out of fear of losing support or approval from others. They may go to great lengths to maintain relationships, even if they are unhealthy.
C. Lacks remorse. Lack of remorse is more characteristic of antisocial personality disorder (ASPD), where individuals show little concern for the rights or feelings of others. In contrast, those with DPD tend to feel excessive guilt and anxiety rather than a lack of remorse.
D. Afraid to be alone. A strong fear of being alone is a core feature of DPD. Individuals may feel helpless or unable to function independently, leading them to tolerate mistreatment or stay in dependent relationships.
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