Which of the following has the highest risk for EPS?

A. Clozapine (Clozaril) does not require food for absorption, but it has a high risk of sedation, weight gain, and metabolic side effects. It also requires regular blood monitoring due to the risk of agranulocytosis.

B. Aripiprazole (Abilify) can be taken with or without food, as food does not significantly affect its absorption. It is a partial dopamine agonist, associated with a lower risk of weight gain and metabolic issues compared to other atypical antipsychotics.

C. Lurasidone (Latuda) must be taken with at least 350 calories of food to ensure proper absorption. Taking it on an empty stomach reduces its bioavailability, making it less effective. It is considered a weight-neutral antipsychotic and has a lower risk of metabolic side effects.

D. Haloperidol (Haldol) does not require food for absorption. It is a first-generation antipsychotic (FGA) with a high risk of extrapyramidal symptoms (EPS) but minimal metabolic effects.

A. Cesar's Assessment Scale. There is no widely recognized Cesar's Assessment Scale for diagnosing ADHD.

B. Hamilton Assessment Scale. The Hamilton scales (HAM-A and HAM-D) are used to assess anxiety and depression, not ADHD. They measure emotional symptoms, somatic complaints, and cognitive impairments associated with mood disorders.

C. Vanderbilt Assessment Scale. The Vanderbilt Assessment Scale is a validated tool used for ADHD diagnosis in children. It assesses inattention, hyperactivity, impulsivity, and associated behavioral problems based on parent and teacher reports. It also screens for common comorbidities such as oppositional defiant disorder (ODD) and anxiety disorders.

D. Columbia Assessment Scale. The Columbia Suicide Severity Rating Scale (C-SSRS) is used to assess suicidal ideation and behavior, not ADHD. It is primarily applied in psychiatric evaluations and crisis intervention settings.