Which of the following has the highest risk for EPS?
aripiprazole (Abilify)
clozapine (Clozaril)
lurasidone (Latuda)
haloperidol (Haldol)
The Correct Answer is D
A. Aripiprazole (Abilify) is a second-generation (atypical) antipsychotic with a lower risk of extrapyramidal symptoms (EPS) due to its partial dopamine agonist mechanism. It has a lower incidence of tardive dyskinesia and dystonia compared to typical antipsychotics.
B. Clozapine (Clozaril) has the lowest risk of EPS among antipsychotics because it weakly blocks D2 receptors and primarily targets serotonin (5-HT2A) receptors. However, it carries a high risk of agranulocytosis, sedation, and metabolic syndrome.
C. Lurasidone (Latuda) is a second-generation antipsychotic with a moderate risk of EPS, particularly akathisia (restlessness). However, it has a lower risk than first-generation (typical) antipsychotics like haloperidol.
D. Haloperidol (Haldol) is a first-generation (typical) antipsychotic with a high risk of EPS due to its strong dopamine (D2) receptor blockade. It is associated with dystonia, akathisia, parkinsonism, and tardive dyskinesia, making it the antipsychotic with the highest EPS risk in this list.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. "Made up" words. This describes neologisms, where individuals create new, nonsensical words that have meaning only to them. It is often seen in schizophrenia and other psychotic disorders.
B. Repeating of another's words. This describes echolalia, a speech disturbance where individuals involuntarily repeat words or phrases spoken by others. It is common in autism spectrum disorder, catatonia, and some neurological conditions.
C. Thought of the speaker wanders off in another direction. Tangentiality occurs when a person's train of thought drifts away from the original topic and never returns to it. Unlike circumstantial speech, where the person eventually returns to the point, tangential thinking leads to incoherent, off-topic responses, commonly seen in schizophrenia, mania, and cognitive disorders.
D. Meaningless rhythm of words. This describes word salad, where speech consists of random, disorganized, and nonsensical words without logical structure. It is a severe thought disorder seen in advanced schizophrenia or delirium.
Correct Answer is C
Explanation
A. Lack of motivation. Avolition, not alogia, refers to a severe lack of motivation to initiate and sustain goal-directed activities. It is a common negative symptom of schizophrenia, leading to difficulties in completing tasks such as hygiene, work, or social activities.
B. No empathy. Lack of empathy is more commonly associated with antisocial personality disorder (ASPD) or narcissistic personality disorder (NPD) rather than schizophrenia. Individuals with schizophrenia may struggle with social interactions, but this is due to cognitive deficits rather than a lack of concern for others.
C. Reduction in quantity of words spoken. Alogia refers to poverty of speech, characterized by diminished verbal output and difficulty generating spontaneous speech. It is a negative symptom of schizophrenia, often presenting as brief, empty responses or difficulty engaging in conversation.
D. Inability to experience pleasure. Anhedonia refers to the inability to feel pleasure in activities that were once enjoyable. It is another negative symptom of schizophrenia and is also seen in major depressive disorder and other mood disorders.
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