Which of the following medications is effective for enuresis?

A. Delusions are a positive symptom of schizophrenia, not a negative symptom. They are false, fixed beliefs that persist despite evidence to the contrary. Common types include persecutory, grandiose, and bizarre delusions. Positive symptoms result from excess dopamine activity in the mesolimbic pathway.

B. Avolition is a negative symptom characterized by a lack of motivation to initiate and sustain goal-directed activities. It leads to difficulties with personal hygiene, work, and social engagement, significantly impairing daily functioning.

C. Apathy is a negative symptom marked by a lack of interest, enthusiasm, or emotional responsiveness. Individuals with schizophrenia may show indifference to social interactions, personal achievements, or daily activities.

D. Alogia (poverty of speech) is a negative symptom where individuals speak less and provide minimal verbal responses. This reflects impaired thought processing and reduced cognitive engagement, common in schizophrenia's mesocortical dopamine pathway dysfunction.

A. Dopamine. Tourette’s syndrome is primarily associated with dopamine dysregulation, particularly increased dopamine activity in the basal ganglia. This overactivity leads to excessive, involuntary motor and vocal tics. Dopamine-blocking medications, such as antipsychotics (e.g., haloperidol, risperidone), can help reduce tic severity.

B. Serotonin. While serotonin plays a role in mood regulation and impulse control, it is not the primary neurotransmitter involved in Tourette’s. However, selective serotonin reuptake inhibitors (SSRIs) may be used to treat co-occurring obsessive-compulsive disorder (OCD) and anxiety symptoms in Tourette’s patients.

C. Glutamate is the brain’s primary excitatory neurotransmitter, involved in learning and memory. While some research suggests glutamate imbalances may contribute to tic severity and compulsive behaviors, dopamine remains the key neurotransmitter in Tourette’s pathology.

D. GABA is the brain’s primary inhibitory neurotransmitter, responsible for reducing neural excitability. Though impaired GABAergic inhibition may contribute to tic generation, the main abnormality in Tourette’s involves dopamine overactivity in the basal ganglia and cortico-striatal-thalamo-cortical circuits.