Which of the following has the lowest risk for sexual dysfunction and weight gain?
clozapine (Clozaril)
olanzapine (Zyprexa)
haloperidol (Haldol)
aripiprazole (Abilify)
The Correct Answer is D
A. Clozapine (Clozaril) is a second-generation (atypical) antipsychotic with a high risk of weight gain, metabolic syndrome, and sedation due to its strong antagonism of histamine (H1) and serotonin (5-HT2C) receptors. It can also cause sexual dysfunction due to its impact on dopamine and prolactin levels.
B. Olanzapine (Zyprexa) has a significant risk of weight gain and metabolic side effects, similar to clozapine. It is known to cause hyperlipidemia, insulin resistance, and increased appetite, contributing to obesity. Sexual dysfunction can occur but is less common than with prolactin-elevating antipsychotics.
C. Haloperidol (Haldol) is a first-generation (typical) antipsychotic with a high risk of sexual dysfunction due to prolactin elevation from strong dopamine (D2) receptor blockade. While it has a lower risk of weight gain than atypical antipsychotics, it carries a high risk of extrapyramidal symptoms (EPS).
D. Aripiprazole (Abilify) is a partial dopamine agonist and has the lowest risk of weight gain among atypical antipsychotics. It also has a minimal impact on prolactin levels, reducing the risk of sexual dysfunction. Due to its unique mechanism, it is often preferred for patients concerned about metabolic side effects and sexual health.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
A. Delusions are a positive symptom of schizophrenia, not a negative symptom. They are false, fixed beliefs that persist despite evidence to the contrary. Common types include persecutory, grandiose, and bizarre delusions. Positive symptoms result from excess dopamine activity in the mesolimbic pathway.
B. Avolition is a negative symptom characterized by a lack of motivation to initiate and sustain goal-directed activities. It leads to difficulties with personal hygiene, work, and social engagement, significantly impairing daily functioning.
C. Apathy is a negative symptom marked by a lack of interest, enthusiasm, or emotional responsiveness. Individuals with schizophrenia may show indifference to social interactions, personal achievements, or daily activities.
D. Alogia (poverty of speech) is a negative symptom where individuals speak less and provide minimal verbal responses. This reflects impaired thought processing and reduced cognitive engagement, common in schizophrenia's mesocortical dopamine pathway dysfunction.
Correct Answer is D
Explanation
A. Stereotypic movements. Repetitive motor behaviors, such as hand-flapping, rocking, and spinning, are characteristic of autism spectrum disorder (ASD). These stereotypic movements serve as self-stimulatory behaviors and may help regulate sensory input.
B. Restricted interest. Individuals with ASD often display intense, fixated interests in specific topics or objects (e.g., an obsession with maps, numbers, or train schedules). These restricted interests are highly focused and often interfere with daily functioning.
C. Social communication deficit. Impaired social interaction and communication are core features of ASD. Affected individuals struggle with understanding social cues, making eye contact, interpreting facial expressions, and engaging in reciprocal conversations.
D. Receptive language dysfunction. While language delays can be present in ASD, receptive language dysfunction (difficulty understanding spoken language) is more characteristic of specific language impairment (SLI) or aphasia rather than ASD. In ASD, deficits in pragmatic (social) communication are more pronounced than in purely receptive language processing.
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