Which of the following is a potential complication of primary immunodeficiency disorders?

Explanation: The correct answer is d. Absence or significantly reduced T cell levels. Severe combined immunodeficiency (SCID) is characterized by a severe deficiency or absence of T cells, which are essential for cell-mediated immunity.

Incorrect choices:

a. Increased levels of circulating B cells are not characteristic of SCID. In SCID, both T and B cell immunity are affected, and the client may have reduced levels of both.

b. Elevated immunoglobulin M (IgM) levels may occur in certain types of immunodeficiency disorders, but it is not a specific finding for SCID.

c. Abnormal antibody response to vaccinations can be observed in various immunodeficiency disorders, but it does not specifically indicate SCID.

Explanation: The correct answer is a. Severe combined immunodeficiency (SCID). SCID is a severe and rare primary immunodeficiency disorder characterized by the absence or severe impairment of both T and B cells, leading to a profound deficiency in cellular and humoral immunity.

Incorrect choices:

b. X-linked agammaglobulinemia (XLA) primarily affects B-cell function, resulting in a lack of mature B cells and low levels of immunoglobulins, but does not typically involve T-cell deficiency.

c. Wiskott-Aldrich syndrome affects platelet function and immune system regulation, but it is not characterized by a deficiency of both T and B cells.

d. Common variable immunodeficiency (CVID) is characterized by reduced levels of immunoglobulins, particularly IgG and IgA, but it does not typically lead to a complete deficiency of both T and B cells.