Which of the following is not true about type 2 diabetes?

Choice A reason: Neuropathy, particularly diabetic neuropathy, is often caused by the thickening, sclerosis (hardening), obstruction, and ischemia (reduced blood flow) of the small blood vessels that supply the nerves (vasa nervorum). This can lead to nerve degeneration, delayed nerve conduction, and impaired sensory function. Over time, high blood glucose levels can damage these small blood vessels, leading to neuropathy.

Choice B reason: While hyperglycemia (high blood glucose levels) is a major factor in the development of diabetic neuropathy, it is the resulting damage to the blood vessels supplying the nerves that directly causes the nerve degeneration and delayed conduction.

Choice C reason: Thickening of blood is not a direct cause of neuropathy. Neuropathy is more directly related to the damage and obstruction of the small blood vessels that supply the nerves.

Choice D reason: Hypoglycemia (low blood glucose levels) does not cause neuropathy. In fact, the acute effects of hypoglycemia are typically neurological symptoms such as confusion, seizures, and loss of consciousness. Chronic nerve damage, as seen in neuropathy, is usually due to prolonged hyperglycemia and its effects on blood vessels.

Choice A reason: Risk factors for type 2 diabetes include hypertension, family history, and obesity. These factors increase the likelihood of developing type 2 diabetes. Hypertension, or high blood pressure, is often seen in individuals with type 2 diabetes due to the correlation between these conditions. A family history of diabetes indicates a genetic predisposition to the disease. Obesity, particularly central obesity (excess fat around the abdomen), is a significant risk factor as it contributes to insulin resistance, a key component in the pathophysiology of type 2 diabetes.

Choice B reason: The onset of type 2 diabetes is typically gradual, which means that it develops slowly over time. Many individuals may have prediabetes for years before their condition progresses to type 2 diabetes. This gradual onset can make it challenging to diagnose early, as symptoms may be mild or absent initially. Early detection through routine screening and awareness of risk factors is essential in managing and preventing the progression of the disease.

Choice C reason: Type 2 diabetes accounts for approximately 90-95% of all diabetes cases. It is the most common form of diabetes and is primarily characterized by insulin resistance and relative insulin deficiency. Unlike type 1 diabetes, where the body's immune system attacks and destroys insulin-producing cells, type 2 diabetes typically develops due to a combination of genetic and lifestyle factors, such as poor diet and lack of physical activity.

Choice D reason: Significant weight loss is not a typical sign of type 2 diabetes. Instead, it is more commonly associated with type 1 diabetes, where the body cannot produce insulin, leading to the breakdown of fat and muscle for energy. In type 2 diabetes, weight loss may occur if blood sugar levels are very high, but it is not a common initial symptom. More commonly, individuals with type 2 diabetes may experience symptoms such as increased thirst, frequent urination, and fatigue.