A nurse is explaining drug metabolism to a nursing student who asks about glucuronidation. The nurse knows that this is a process that allows drugs to be:

Excreted in hydrolyzed form in the feces to reduce drug toxicity.

Transported across the renal tubules to be excreted in the urine.

Recycled within the enterohepatic recirculation to remain in the body longer.

Reabsorbed from the urine into the renal circulation to minimize drug loss.

Answer and Explanation

The Correct Answer is B

Choice A reason: Glucuronidation does not primarily involve fecal excretion; it conjugates drugs for urinary excretion. Hydrolysis is unrelated, and fecal routes are secondary, so this is incorrect for glucuronidation’s role.

Choice B reason: Glucuronidation conjugates drugs, making them water-soluble for transport across renal tubules and excretion in urine. This is the primary mechanism, making it the correct choice for drug elimination.

Choice C reason: Enterohepatic recirculation involves some drugs, but glucuronidation aims for excretion, not recycling. Prolonging drug presence is not the goal, so this is incorrect for the process.

Choice D reason: Glucuronidation facilitates excretion, not reabsorption. Reabsorbing drugs would counteract its purpose of eliminating metabolites, making this incorrect compared to urinary excretion.

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Correct Answer is C

Explanation

Choice A reason: ACE inhibitors are teratogenic, risking fetal harm, so monitoring while continuing is unsafe. Stopping the drug is critical, making this incorrect for safe pregnancy management.

Choice B reason: ARBs are also contraindicated in pregnancy due to similar teratogenic risks. Switching to an ARB is not safe, so this is incorrect compared to stopping the medication.

Choice C reason: ACE inhibitors can cause fetal abnormalities, so the patient must stop the medication and contact her provider immediately for safer alternatives. This is the correct action.

Choice D reason: Continuing ACE inhibitors, even adjusted, is dangerous in pregnancy due to teratogenicity. Immediate cessation and provider consultation are required, making this incorrect.

A. 1.4 mL B. 1.8 mL C. 1.2 mL D. 1.6 mL

Correct Answer is D

Explanation

Choice A reason: To calculate the volume, divide the ordered dose (8 mg) by the concentration (5 mg/mL): 8 ÷ 5 = 1.6 mL. Choice A (1.4 mL) underestimates the volume, delivering only 7 mg (1.4 × 5), which is insufficient for the prescribed dose, making it incorrect for accurate medication administration.

Choice B reason: Calculating 8 mg ÷ 5 mg/mL yields 1.6 mL. Choice B (1.8 mL) would deliver 9 mg (1.8 × 5), exceeding the ordered dose. This overdose could increase the risk of sedation or respiratory depression, as Valium (diazepam) is a benzodiazepine with potent CNS effects, making this choice incorrect.

Choice C reason: The correct volume is 8 mg ÷ 5 mg/mL = 1.6 mL. Choice C (1.2 mL) delivers only 6 mg (1.2 × 5), which is below the prescribed dose. This underdose could result in inadequate therapeutic effects, such as insufficient anxiety relief or seizure control, making it an incorrect choice.

Choice D reason: Dividing the ordered dose (8 mg) by the concentration (5 mg/mL) gives 8 ÷ 5 = 1.6 mL. This volume accurately delivers the prescribed 8 mg of Valium, ensuring therapeutic efficacy for conditions like anxiety or seizures while minimizing risks of over- or under-dosing, making it the correct choice.

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A nurse is explaining drug metabolism to a nursing student who asks about glucuronidation. The nurse knows that this is a process that allows drugs to be:

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Naxlex Comprehensive Predictor Exams

A female patient taking an ACE inhibitor learns that she is pregnant. What will the nurse tell this patient?

Correct Answer is C

Explanation

The healthcare provider orders Valium 8 mg IV now. The concentration available is 5 mg/mL. How many mL will the patient receive?

Correct Answer is D

Explanation

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