A thyrotoxic crisis is a complication of which disorder?

A. Primary immunodeficiency involves a developmental failure in the bone marrow or thymus, impairing immune system development. This aligns with the question, as primary immunodeficiencies, such as severe combined immunodeficiency or DiGeorge syndrome, result from genetic defects affecting lymphocyte development, crucial for meeting physiological needs in Maslow’s hierarchy.

B. Secondary immunodeficiency results from external factors like infections or malnutrition, not developmental failure in the bone marrow or thymus. This does not fit the question, as it lacks a congenital basis.

C. Autoimmune disorders arise from immune system dysfunction attacking self-tissues, not developmental failure in immune organs. This is unrelated to the question’s focus on developmental defects.

D. Infections are a consequence of primary immunodeficiency due to impaired T-cell or B-cell function, increasing susceptibility to recurrent bacterial, viral, or fungal infections. This fits the question, as immunodeficiency predisposes individuals to infections.

E. Allergies result from immune overreactions to harmless substances, not a direct consequence of developmental immune defects. This does not align with the question’s focus on immunodeficiency outcomes.

F. Autoimmune diseases involve immune attacks on self-tissues, not a primary outcome of developmental immune failure. This is incorrect for the question’s context.

G. Malignancies are a known complication of primary immunodeficiencies, as impaired immune surveillance increases cancer risk, particularly lymphomas or leukemias. This aligns with the question’s focus on outcomes of immunodeficiency.

H. Chronic pain is not a direct result of immunodeficiency or developmental failure in the bone marrow or thymus. This does not fit the question’s scope.

I. Recurrent infections are a hallmark of primary immunodeficiency, as defective immune components fail to protect against pathogens. This aligns with the question, as it directly results from immune system developmental failure.

Choice A reason: Air trapping in COPD, due to alveolar destruction and loss of elasticity, causes lung overinflation, increasing the anteroposterior chest diameter, resulting in a barrel chest. This is a direct consequence, making this the correct choice.

Choice B reason: Cyanosis occurs in COPD from hypoxia due to impaired gas exchange, not directly from air trapping. While common in advanced disease, it is not the primary manifestation of overinflation, making this incorrect.

Choice C reason: Clubbed fingers result from chronic hypoxia in COPD, not directly from air trapping. They develop over time due to tissue remodeling, not lung overinflation, making this choice incorrect.

Choice D reason: Lack of appetite is a systemic symptom in advanced COPD due to energy expenditure or hypoxia, not a direct result of air trapping or lung overinflation, making this choice incorrect.