In DiGeorge disease, what is the cause? (Select all that apply)
Lack of development of the thymus
B cells cannot mature
T cells cannot mature
Lack of development of the bursa
Correct Answer : A,C
Choice A reason: DiGeorge disease involves thymic hypoplasia or aplasia, impairing T-cell development. This is a primary cause, leading to immune deficiency, making it a correct choice for the condition’s etiology.
Choice B reason: B-cell maturation is generally preserved in DiGeorge disease, as it primarily affects T-cells due to thymic defects. T-cell issues are central, so this is incorrect for the cause.
Choice C reason: T cells cannot mature in DiGeorge disease due to thymic underdevelopment, causing severe immunodeficiency. This is a core feature of the syndrome, making it a correct choice for the cause.
Choice D reason: Humans lack a bursa; B-cell maturation occurs in bone marrow. DiGeorge affects the thymus and T-cells, not a nonexistent bursa, so this is incorrect for the cause.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: Vitamin D deficiency affects calcium and bone health, not creatinine or BUN levels, which reflect kidney function. Elevated BUN and creatinine point to dehydration or kidney issues, so this is incorrect for the lab findings.
Choice B reason: Elevated creatinine and BUN indicate dehydration or kidney dysfunction, as these markers rise when kidneys fail to clear waste or when blood volume is low. This matches the patient’s symptoms, making it the correct choice.
Choice C reason: Respiratory acidosis affects blood pH and CO2, not creatinine or BUN, which are renal markers. Kidney dysfunction or dehydration better explain the lab results, so this is incorrect for the findings.
Choice D reason: Liver failure may elevate other markers (e.g., bilirubin), but BUN and creatinine are kidney-specific. Dehydration or kidney dysfunction align with the labs and symptoms, so this is incorrect.
Correct Answer is D
Explanation
Choice A reason: Immune thrombocytopenic purpura (ITP) causes isolated thrombocytopenia due to autoimmune platelet destruction, leading to bleeding like petechiae. However, it does not typically cause prolonged PT/aPTT, elevated D-dimer, or DVT, making it inconsistent with Lorretta’s multi-system coagulopathy.
Choice B reason: Thrombotic thrombocytopenic purpura (TTP) involves microangiopathic hemolytic anemia, thrombocytopenia, and organ damage but typically presents with neurological or renal symptoms, not prolonged PT/aPTT or DVT. Lorretta’s coagulopathy and DVT history better align with another condition, making TTP incorrect.
Choice C reason: Hemophilia, a genetic clotting factor deficiency, causes prolonged aPTT but not thrombocytopenia, elevated D-dimer, or DVT. It primarily affects males and causes joint or muscle bleeds, not diffuse bleeding like Lorretta’s, making this an incorrect diagnosis.
Choice D reason: Disseminated intravascular coagulation (DIC) involves widespread clotting and bleeding, causing thrombocytopenia, prolonged PT/aPTT, elevated D-dimer, and petechiae. Lorretta’s DVT history and anticoagulant use may trigger DIC, with leg swelling indicating thrombosis, making this the correct diagnosis.
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