Portal hypertension from liver cirrhosis may cause which manifestation?

Choice A reason: Pyelonephritis, a bacterial kidney infection, causes intrarenal AKI by directly damaging renal parenchyma through inflammation and tubular injury. The infection disrupts nephron function, reducing filtration and leading to acute kidney injury, making this a correct cause of intrarenal damage.

Choice B reason: Nephrotoxins, such as certain drugs or chemicals, cause intrarenal AKI by directly injuring tubular epithelial cells. This disrupts renal filtration and reabsorption, leading to acute kidney injury through toxic cellular damage, making this a correct cause of intrarenal AKI.

Choice C reason: A bladder tumor causes postrenal AKI by obstructing urine outflow, leading to backpressure on the kidneys. It does not directly damage renal parenchyma, as intrarenal AKI requires, making this choice incorrect for intrarenal causes of kidney injury.

Choice D reason: Dehydration causes prerenal AKI by reducing blood volume and renal perfusion, not directly damaging the renal parenchyma. Intrarenal AKI involves intrinsic kidney damage, so dehydration’s hypoperfusion effect makes this choice incorrect for intrarenal AKI.

Choice E reason: Ureteral obstruction causes postrenal AKI by blocking urine flow, increasing pressure on the kidneys. It does not involve direct parenchymal damage, as required for intrarenal AKI, making this choice incorrect for the specified type of kidney injury.

Choice A reason: Chronic asthma involves persistent symptoms managed over time, not an acute, life-threatening event. Status asthmaticus is an acute, severe exacerbation unresponsive to standard treatments, requiring urgent intervention, making this choice incorrect for describing status asthmaticus.

Choice B reason: An asthma attack triggered by exercise is exercise-induced bronchospasm, not status asthmaticus. Status asthmaticus is a severe, prolonged attack resistant to therapy, not defined by a specific trigger like exercise, making this choice incorrect.

Choice C reason: A mild asthma attack resolving with bronchodilators responds to standard therapy, unlike status asthmaticus, which is a severe, life-threatening attack unresponsive to bronchodilators and corticosteroids, requiring intensive care, making this choice incorrect for the condition.

Choice D reason: Status asthmaticus is a severe, prolonged asthma attack that does not respond to standard treatments like bronchodilators and corticosteroids. It causes critical airway obstruction and hypoxia, requiring aggressive medical intervention, accurately describing the condition and making this the correct choice.