The nurse gives medication to a patient with a history of liver disease. The nurse will monitor this patient for
Decreased drug effects.
Increased drug effects.
Decreased therapeutic range.
Increased therapeutic range.
The Correct Answer is B
a) Decreased drug effects are unlikely in liver disease because impaired liver function reduces drug metabolism, leading to higher drug concentrations in the bloodstream.
b) Increased drug effects occur because the liver is responsible for metabolizing many drugs. In liver disease, drug metabolism is slowed, leading to prolonged drug action and potential toxicity.
c) Decreased therapeutic range is not the primary concern. The therapeutic range refers to the safe and effective drug concentration, but liver disease mainly affects drug metabolism and clearance.
d) Increased therapeutic range is incorrect because liver disease does not widen the range of safe drug levels; instead, it increases the risk of drug accumulation and toxicity.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
A. While medication adherence is important, the primary reason for asking about alternative therapies is not due to concerns about compliance. Patients may use alternative therapies alongside prescribed medications, potentially leading to harmful interactions.
B. Many complementary and alternative therapies, such as herbal supplements, can interact with prescribed medications, leading to adverse effects or reduced drug efficacy. For example, St. John’s Wort can decrease the effectiveness of certain medications, including anticoagulants and antidepressants. Identifying these therapies ensures patient safety.
C. While some natural products may have therapeutic benefits, they are not necessarily more effective than prescribed medications. Healthcare providers should base treatment decisions on evidence-based practice rather than assuming an alternative therapy is superior.
D. Financial concerns are important but not the primary reason for inquiring about alternative therapies. The nurse’s main concern is the potential for harmful drug interactions rather than the cost burden on the patient.
Correct Answer is A
Explanation
A. Bioavailability refers to the proportion of a drug that enters systemic circulation and is available for therapeutic effect. Generic drugs must demonstrate bioequivalence to brand-name drugs, meaning their bioavailability must be within an acceptable range to ensure similar efficacy.
B. Critical concentration is the minimum drug level required to produce a therapeutic effect, but it is not the primary factor in generic drug substitution.
C. Distribution refers to how a drug is transported in the body after absorption, but it is not the main concern when substituting generic drugs.
D. Half-life is the time required for the drug concentration to decrease by half in the body, but it does not determine whether a generic drug can replace a brand-name drug. Bioavailability is the key factor in ensuring therapeutic equivalence.
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