Which of the following factors contributes to the development of osteoarthritis?
Chronic inflammation of the synovial membrane
Hyperactivity of the immune system
Deficiency of collagen in joint cartilage
Excessive physical activity and joint overuse
The Correct Answer is D
Excessive physical activity and joint overuse can contribute to the development of osteoarthritis. Repetitive use and mechanical stress on the joints can lead to cartilage degeneration over time.
a. Osteoarthritis is primarily a non-inflammatory condition. Chronic inflammation of the synovial membrane is more characteristic of other types of arthritis, such as rheumatoid arthritis.
b. Osteoarthritis is not related to hyperactivity of the immune system. It is not an autoimmune disease, and the immune system is not involved in its pathogenesis.
c. Collagen is an essential component of joint cartilage. A deficiency of collagen would weaken the cartilage and contribute to joint degeneration. However, osteoarthritis is not primarily caused by collagen deficiency.
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Correct Answer is C
Explanation
Pain that worsens with weight-bearing activities and improves with rest is a classic clinical manifestation of osteoarthritis. Activity-related pain is due to the increased stress on the affected joint during movement, while rest allows for decreased pressure and relief of pain.
a. Nocturnal joint pain is more typical of inflammatory arthritis conditions like rheumatoid arthritis, not osteoarthritis.
b. Morning joint stiffness lasting for 1 hour is characteristic of inflammatory arthritis conditions like rheumatoid arthritis, not osteoarthritis.
d. Joint pain that is constant throughout the day may be seen in various joint disorders, but the pattern of pain relief with activity is more indicative of osteoarthritis.
Correct Answer is D
Explanation
Obesity is a primary risk factor for the development of osteoarthritis, particularly in weight-bearing joints such as the knees and hips. Excess weight puts increased stress on the joints, leading to cartilage breakdown and the development of osteoarthritis. While age, family history, and a sedentary lifestyle can also contribute to the development of osteoarthritis, obesity is the most significant risk factor.
a. While age over 65 years is a risk factor for osteoarthritis, it is not the primary risk factor. Osteoarthritis can occur at any age, especially if other risk factors are present.
b. Family history of osteoporosis is not a primary risk factor for osteoarthritis. Osteoarthritis and osteoporosis are separate conditions with different risk factors.
c. While a sedentary lifestyle can contribute to the development of osteoarthritis, it is not the primary risk factor. Obesity is a more significant risk factor in this context.
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